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KMID : 0608520020080010065
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Korean Journal of Oriental Medicine
2002 Volume.8 No. 1 p.65 ~ p.74
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COX-2 Inhibition and Anti-inflammatory Effects of Traditional Herbal Medicine
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Kim Yun-Kyung
Ha Hye-Kyeong
Lee Jae-Hyun
Kim Chung-Sook
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Abstract
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Inflammation is a disease that continues to afflict large numbers of people and may cause other diseases, for example, rheumatoid arthritis, colon cancer, etc. prostaglandins(PGs), one of arachidonic acid metabolites, are major chemical mediators in the process of inflammation. In traditional herbal medicine, many kinds of herbal drugs have been widely used for the treatment of inflammation. So, we analyzed many publications until 2001 which worked on inhibition of synthesis by cyclooxygenase-2 (COX-2) with herbs and herb oriented single compounds. And then we tried to make interpretations of herbal traditional prescriptions for inflammation. There are significant correlations between herbal medicine prescribed and inhibitions of COX-2 activity. From our efforts and further researches, we expect to develop new-inflammatory herbal drugs which have more efficacy and fewer side effects.
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KEYWORD
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COX-2, Inhibition, Herbal medicine, Inflammation, Prescriptions
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